Do we have something like this 🤔

Internals & Design
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PGO would be great to explore in the context of JuliaInterpreter (“interpret unless it’s a bottleneck, then compile”), but that might be different than what you’re after.

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It seems also interesting to use PGO in order to optimize the LLVM part of the compiler, no? It appears pretty straightforward to do, according to the first part in the link.