Well, == is user-defined, so anything:
julia> struct MyType
x::Int
end
# This is probably a bad idea, but there's no reason you *can't* do it
julia> Base.:(==)(m::MyType, ::Nothing) = true
julia> MyType(1) == nothing
true
But === is always a test for actual equivalence, so even weird user code can’t override it:
julia> MyType(1) === nothing
false