Streaming gziped file to FASTQ.Reader - where to add method?

Have you tried CodecZlib? I use it all the time to read gzip files directly as if I were reading an uncompressed file.

A side benefit is that it is the fastest reader I’ve found for gzip compressed files.

Oops, may not work for you as it is also based on TranscodingStreams. Would still be worth trying it.

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