I think the shortest path for making PyJulia easier to use is RFC: a "workaround" for the multi-project precompilation cache problem without long-term code debt with Make PyCall.jl AOT-compilable by tkf · Pull Request #651 · JuliaPy/PyCall.jl · GitHub. (The idea is to create a system image for PyJulia and let Julia automatically use precompilation cache dedicated to PyJulia.) Maybe you can help me in that thread 
I also added Julia option support recently (available only in master). You can use Julia(compiled_modules=False) to workaround the compilation cache problem: Troubleshooting — PyJulia 0.5.8.dev documentation It would make PyJulia setup plug-and-play if you are OK with waiting for precompilation for each Python process (yeah, I know this is not super practical for all purposes).