just pass the column names you want:
julia> transform(s, :grid => (ByRow(x -> split(x,"_"))) => [:col1, :col2])
3×4 DataFrame
Row │ grid e col1 col2
│ String Int64 SubStrin… SubStrin…
─────┼─────────────────────────────────────────
1 │ uuu_mygrid 3 uuu mygrid
2 │ uuu_mygrid 3 uuu mygrid
3 │ uuu_mygrid 3 uuu mygrid