The Spanish keyboard (QWERTY - Wikipedia) needs AltGr+3 (“#”), followed by Shift+0 (“=”) to typeset “#=”. This is slightly more complex than on my Norwegian keyboard, where I type Shift+3 (“#”) followed by Shift+0 (“=”) – which is relatively straightforward for touch typists. I realize that the Shift key is easier to reach than the AltGr key (two shift keys + easier to reach).
The Latin American keyboard (QWERTY - Wikipedia) needs Shift+3 to typeset “#”, just like my Norwegian keyboard, and Shift+0 for “=”. Thus, fairly easy for a touch typist.