Why? Keep in mind that Julia is a compiler, the performance of the code it generates doesn’t depend on how it was compiled. There can be a little improvement in the performance of Julia’s runtime, but the benchmarks in Compiling Julia using LTO+PGO - #5 by stabbles showed negligible speedup when compiling Julia and all of its dependencies with -march=native. You mention large multi-node jobs, but if you’re referring to MPI, the package MPI.jl does dynamic loading, so compiling Julia locally doesn’t have any advantages compared to using a prebuilt generic binaries of Julia. Or were you thinking of something else?