Annotation for each row and column of subplots in layout, plot by column in layout, copy figure

For (1), one method might be to use linebreaks (\n) in the ylabel and title keywords using Plots:

using Plots, Plots.PlotMeasures
gr(size=(1200,800), xtickfontsize=13, ytickfontsize=13, xguidefontsize=16, yguidefontsize=20, legendfontsize=12, titlefontsize=20, dpi=100)
offsetlines = plot(rand(10), ylabel="top line \n \n \n bottom line", title="top line \n \n \n  bottom line", margin=10mm)
savefig(offsetlines, "offsetlines.png")

which produces the following:

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